Effect of different hydroxyapatite:β-tricalcium phosphate ratios on the osteoconductivity of biphasic calcium phosphate in the rabbit sinus model
AUTHOR
-- BY Lim HC, Zhang ML, Lee JS, Jung UW, Choi SH
Purpose: This study compared the volume stability and bone-forming capacity of biphasic calcium phosphate (BCP) with a high versus a low ratio of (β-tricalcium phosphate (β-TCP) relative to hydroxyapatite (HA), i.e., 70:30 vs 30:70, in the rabbit sinus model.
Materials and methods: Bilateral sinus
windows were created in eight adult New Zealand white rabbits (2.5 to 3.5 kg);
each sinus in each rabbit was assigned to one of two experimental BCP groups
according to the HA: β-TCP ratio. One sinus was grafted with BCP with a high
ratio of β-TCP (30:70; TCP70), and the contralateral sinus was grafted with BCP
with a low ratio of β-TCP (70:30; TCP30). The animals were sacrificed after 2
weeks (n = 4) or 8 weeks (n = 4) of healing. Biopsy specimens were harvested
and evaluated histologically, histomorphometrically, and with microcomputed
tomography.
Results: The bone volume did not differ
significantly between the two groups at each healing point, or between 2 and 8
weeks of healing in both groups. The amount of new bone increased significantly
between 2 and 8 weeks of healing in both groups, and it did not differ
significantly between the TCP30 and TCP70 groups. The residual material was
significantly more resorbed in the TCP70 group than in the TCP30 group at both
2 and 8 weeks. In the TCP70 group, a greater number of multinucleated giant
cells were observed at both weeks. The bone-to-residual material contact ratio
did not differ significantly between the two groups.
Conclusion: The volume stability and osteoconductive
capacity of BCP with an HA: β-TCP ratio of 30:70 was comparable to that with an
HA: β-TCP ratio of 70:30. Thus, within the limitations of this study, it can be
argued that BCP with an HA: β-TCP ratio of 30:70 can be successfully used for
sinus augmentation.
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